Clinical evaluation of lipids, lipoproteins and red blood cells sodium and potassium in patients with different grades of hypertension.

OBJECTIVES To show that lipid and lipoprotein levels and cell sodium and potassium content and transport could change depending on the degree of hypertension. DESIGN AND METHODS Forty-three hypertensive patients and 20 healthy subjects were recruited at the Cardiology and Biochemistry Departments of Tlemcen University Hospital Centre (Northwest of Algeria). RESULTS Levels of CHOL, TG, PL, HDL-TG, LDLc, LDL-TG, LDL-PL, HDL2-TG and HDL3-TG were significantly higher in hypertensive patients than those in controls. HDL-PL levels were significantly lower in patients compared with controls and decreased according to the grade of hypertension. HDL2c, HDL2-PL and HDL3-TG and cell content and fluxes of sodium and potassium change gradually with higher grades of hypertension. CONCLUSIONS Hypertensive patients with circulating lipid alterations are associated to ion cell content and transport abnormalities, which were worsened progressively with higher grade of hypertension.